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Once the piercing has finished the first stage of healing and is no longer an open wound, you can change the jewelry. Taking the jewelry only out to be replaced within a short period of time.
The second stage of healing where the body produces layer upon layer of additional skin and may in some case, take up to 3-4 years to complete. Removing the jewelry for long periods of time during this phase of healing can cause the piercing to close or shirk. Shrinking of the piercing hole will not only make replacing the jewelry difficult but if the jewelry is forced back it it can tear the piercing tunnel. If the tunnel is torn or dislodged then the piercing will have to be healed all over again. Forcing the jewelry back in can also create thin areas or stretch marks in the piercing tunnel. Even in a well healed piercing, if you remove the jewelry for long periods of time you can loses the piercing. This is especially true in fast healing areas of the body like the mouth. Word to the wise, if you feel that your employer is going to ask you to remove the jewelry during work hours, then you should consider getting a piercing that is less visible.

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